Ligand id: 7365

Name: dolutegravir

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 99.18
Molecular weight 419.13
XLogP 1.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in conjunction with other antiretrovial agents in the treatment of HIV-1 infection in adults and children aged over 12 years weighing over 40kg.
Mechanism Of Action and Pharmacodynamic Effects
Prevents retroviral DNA integration by binding to the active site of HIV integrase and blocking strand transfer.