Ligand id: 7368

Name: sofosbuvir

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 162.54
Molecular weight 529.16
XLogP 1.86
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in combination therapy to treat hepatitis C viral infection with or without co-infection with HIV.
Mechanism Of Action and Pharmacodynamic Effects
Prevents HCV viral replication by inhibiting HCV NS5B polymerase.
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