raltitrexed

Ligand id: 7403

Name: raltitrexed

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 5
Rotatable bonds 10
Topological polar surface area 176.31
Molecular weight 459.13
XLogP 1.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat colorectal cancer and malignant mesothelioma.
Mechanism Of Action and Pharmacodynamic Effects
Ralitrexed inhibits the enzymatic activity of thymidylate synthase thereby reducing the synthesis of precursor pyrimidine nucleotides. This prevents the formation of DNA and RNA and subsequently results in cell death.
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