afegostat

Ligand id: 7410

Name: afegostat

Abbreviated name: IFM

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 1
Topological polar surface area 72.72
Molecular weight 147.09
XLogP -0.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK
No information available.
Summary of Clinical Use
Afegostat is an experimental drug for the treatment Gaucher's disease, which is caused by mutations in the β-glucocerebrosidase gene (GBA, P04062). This drug (as isofagomine tartrate) has been granted orphan status by the European Medicines Agency for this indication.
Mechanism Of Action and Pharmacodynamic Effects
Afegostat binds β-glucocerebrosidase (GBA, P04062), a lysosomal enzyme that hydrolyses glucocerebroside as a step in glycolipid metabolism.