Ligand id: 7438

Name: methacholine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 26.3
Molecular weight 160.13
XLogP 0.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used clinically as a tool to diagnose asthma in a methacholine challenge test that causes bronchoconstriction, and in which asthmatics will react to lower doses of drug.
Mechanism Of Action and Pharmacodynamic Effects
Mechanistically mimics the muscarinic actions of acetylcholine as a bronchoconstrictor.