mercaptamine

Ligand id: 7440

Name: mercaptamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 64.82
Molecular weight 77.03
XLogP 0.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The bitartrate and hydrochloride salt forms are indicated for the treatment of neuropathic cystinosis, and to treat radiation sickness. Link to ClinicalTrials.gov to view currently registered trials assessing efficacy of this drug for additional indications.
Mechanism Of Action and Pharmacodynamic Effects
The inherited lysosomal storage disease, cystinosis is characterized by the abnormal accumulation of the amino acid cystine and arises through inheritance of mutations in the lysosomal cystine transporter gene (CTNS, O60931). Intracellular cystine accumulation and crystallization causes widespread tissue damage. The free thiol group of cysteamine cleaves the disulphide bond in cystine, thereby allowing excretion of the cystine byproducts.