taliglucerase alfa

Ligand id: 7444

Name: taliglucerase alfa

No information available.
Summary of Clinical Use
Taliglucerase alfa is approved to be used as an enzyme replacement therapy for Gaucher's disease patients, whose own β-glucocerebrosidase is non-functional.
Mechanism Of Action and Pharmacodynamic Effects
Taliglucerase alfa is a glucocerebroside hydrolytic enzyme. The enzyme β-glucocerebrosidase (GBA, P04062), is a lysosomal enzyme that hydrolyses glucocerebroside as a step in glycolipid metabolism. β-glucocerebrosidase activity is impaired in Gaucher's disease and this results in accumulation of glucocerebroside.