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Synonyms: Jetrea® | microplasmin
ocriplasmin is an approved drug (FDA (2012), EMA (2013))
Compound class:
Peptide or derivative
Comment: Ocriplasmin is a synthetic form of the serine protease, plasmin. It contains a truncated heavy chain peptide sequence and full length light chain. Sequences can be found in the DrugBank entry.
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| No information available. |
Summary of Clinical Use  |
| Approved to treat symptomatic vitreomacular adhesion. |
| Mechanism Of Action and Pharmacodynamic Effects |
| Ocriplasmin can degrade various structural proteins, including laminin and fibronectin, which are localized in the vitreoretinal surface and bind the vitreous humour to the retina [1]. Orciplasmin dissolves abnormally strong bonding between the vitreous humour and retina which can cause pathological vitreomacular traction and subsequent ocular damage. |
| External links |
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For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com European Medicines Agency (EMA) |
