aclidinium

Ligand id: 7449

Name: aclidinium

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 112.24
Molecular weight 484.16
XLogP 5.13
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved to treat and prevent bronchospasm in adults with chronic bronchitis, emphysema, or other forms of chronic obstructive pulmonary disease (COPD) [1]. This drug can be used as long-term maintainence therapy and requires use only once daily. In November 2014, the EU EMA granted marketing authorisation of the fixed-dose combination medication Duaklir Genuair TM (aclidinium bromide/formoterol fumarate) as a maintenance bronchodilator for patients with chronic obstructive pulmonary disease (COPD).
Mechanism Of Action and Pharmacodynamic Effects
Aclidinium bromide is a long-acting, anticholinergic/antimuscarinic bronchodilator [2]. The drug competitively and reversibly inhibits the action of acetylcholine at type 3 muscarinic (M3) receptors in bronchial smooth muscle. This causes a reduction in smooth muscle contraction, ie the bronchodilatory effect that eases breathing.
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