carglumic acid

Ligand id: 7458

Name: carglumic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 129.72
Molecular weight 190.06
XLogP -1.78
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved to treat hyperammonaemia in patients with N-acetylglutamate synthase deficiency, or of other aetiologies.
Mechanism Of Action and Pharmacodynamic Effects
Carglumic acid is a synthetic structural analogue of N-acetylglutamate (NAG). NAG is an essential allosteric activator of carbamoyl-phosphate synthase 1 (CPS1, P31327) in the liver. CPS1 is a mitochondrial enzyme, responsible for catalysing the first step of the urea cycle, which converts ammonia into urea. Drug-induced enhanced activity of CPS1 therefore helps reduce blood ammonia levels in patients with hyperammonaemia.
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