lurasidone

Ligand id: 7461

Name: lurasidone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 84.99
Molecular weight 492.26
XLogP 4.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved to treat adults with schizophrenia and major depressive episodes associated with bipolar I disorder
Mechanism Of Action and Pharmacodynamic Effects
This drug antagonises activity of the dopamine D2-like receptors and serotonin 5-HT2A and 5-HT7 receptors [1]. It also has partial agonist activity at the 5-HT1A receptor [1]. There is no measurable binding to histamine H1 and muscarinic acetylcholine receptors. The overall drug-induced effect is anxiolytic- and antidepressant-like in nature. Lurasidone activity at hippocampal 5-HT7 receptors may deliver procognitive benefits in schizophrenia patients [1].
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