alvimopan

Ligand id: 7471

Name: alvimopan

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 89.87
Molecular weight 424.24
XLogP 5.71
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved to prevent postoperative disruption or failure of peristalsis (ileus), and thereby improve gastrointestinal recovery subsequent to large or small bowel resection.
Mechanism Of Action and Pharmacodynamic Effects
Alvimopan is a μ opioid receptor antagonist, inhibiting activity of peripheral (gastrointestinal) receptors.
External links