tapentadol

Ligand id: 7477

Name: tapentadol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 23.47
Molecular weight 221.18
XLogP 3.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Tapentadol is approved to treat moderate to severe pain.
Mechanism Of Action and Pharmacodynamic Effects
Tapentadol functions as a μ-opioid receptor agonist and as an inhibitor of norepinephrine reuptake via the norepinephrine transporter (NET) [1-2]. It is hypothesised that combining μ-opioid receptor agonist activity with enhanced monoamine activity (eg by inhibiting NET) additively/synergistically enhances the analgesic efficacy of selectve μ-opioid receptor agonists and may reduce their side effects [2] .
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