Ligand id: 7480

Name: trospium

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 46.53
Molecular weight 392.22
XLogP 6.1
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Trospium chloride is a muscarinic antagonist used clinically as a urinary antispasmodic, indicated for the treatment of overactive bladder syndrome.
Mechanism Of Action and Pharmacodynamic Effects
Trospium chloride is a muscarinic antagonist [1]. The parasympatholytic action of trospium chloride, induces relaxation of the detrusor muscle in the wall of the bladder and reduces over all muscle tone in the bladder, thereby increasing volume and decreasing the symptoms of urge incontinence, urgency, and urinary frequency associated with overactive bladder syndrome.
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