cobicistat

Ligand id: 7535

Name: cobicistat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 3
Rotatable bonds 24
Topological polar surface area 194.5
Molecular weight 775.35
XLogP 8.36
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a pharmacokinetic booster, to enhance systemic exposure to anti-HIV drugs.
Mechanism Of Action and Pharmacodynamic Effects
Cobicistat inhibits metabolic liver enzymes, in particular the cytochrome P450 3A subtype, CYP3A4 [3]. The CYP3A enzymes are known to breakdown and inactivate antiviral drugs such as elvitegravir (an HIV integrase inhibitor), although cobicistat has no intrinsic antiviral activity [2]. Additionally, cobicistat appears to inhibit intestinal transport proteins, thus increasing absorption of other anti-HIV drugs such as atazanavir, darunavir and tenofovir alafenamide fumarate [1].