dexbrompheniramine

Ligand id: 7588

Name: dexbrompheniramine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 16.13
Molecular weight 318.07
XLogP 4.63
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat allergic conditions such as hay fever or urticaria.
Drugs@FDA lists oral, single agent dexbrompheniramine medications as discontinued. Individual national approval agencies may have granted marketing authorisation for this drug.
Mechanism Of Action and Pharmacodynamic Effects
Dexbrompheniramine blocks the action of endogenous histamine at the histamine H1 receptor. This drug may also have anticholingeric /antimuscarinic action which is likely to contribute to the drug's side effects, which include drowsiness, dry mouth and throat and increased heart rate.