Ligand id: 7590

Name: etonogestrel

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View more information in the IUPHAR Pharmacology Education Project: etonogestrel

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 37.3
Molecular weight 324.21
XLogP 3.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Etonogestrel is the active progestin in several hormonal contraceptives.
Mechanism Of Action and Pharmacodynamic Effects
Etonogestrel is an agonist of the progesterone receptor. Artificial maintainence of high levels of circulating progesterone feeds back to reduce the frequency of gonadotrophin-releasing hormone (GnRH) pulses which blunts the pre-ovulatory lutenising hormone (LH) surge, and the ovaries cease cyclic ovulation.
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