levorphanol

Ligand id: 7595

Name: levorphanol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 23.47
Molecular weight 257.18
XLogP 3.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat moderate to severe pain, including potentially, neuropathic pain [3].
Mechanism Of Action and Pharmacodynamic Effects
Levorphanol is a μ opioid receptor agonist. Activation of this receptor on central nervous system neurons inhibits intracellular adenylate cyclase. Downstream this leads to reduced calcium influx via membrane calcium channels, and increased potassium permeability by opening membrane potassium channels. This ultimately leads to hyperpolarization of the cell membrane potential and suppression of action potential transmission of ascending pain pathways. Antagonist activity at NMDA receptors may be useful in the treatment of neuropathic pain which is unresponsive to other pain medications [3].
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