Ligand id: 7598

Name: acitretin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 46.53
Molecular weight 326.19
XLogP 6.03
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat psoriasis. Due to the level of side effects associated with this drug its use is usually restricted to patients with very severe and resistant psoriasis.
Mechanism Of Action and Pharmacodynamic Effects
Psoriasis is characterised by aberrant growth of skin cells. Retinoid-induced activation of RAR modulates the expression of genes essential for regulating cell proliferation and differentiation. These drugs may also possess immunomodulatory and anti-inflammatory activities and may inhibit ornithine decarboxylase, an action likely to decrease polyamine synthesis and keratinization. In this way acitretin helps to normalize the growth cycle of skin cells. The precise MMOA has still to be confirmed.
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