benzatropine

Ligand id: 7601

Name: benzatropine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 12.47
Molecular weight 307.19
XLogP 6.85
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the symptomatic treatment of Parkinson's disease. May also be used to treat extrapyramidal symptoms, such as dystonia and Parkinsonism, which can be side effects of some antipsychotic drugs such as chlorpromazine, fluphenazine and perphenazine.
Mechanism Of Action and Pharmacodynamic Effects
Benzatropine is a centrally acting antagonist of muscarinic acetylcholine receptors. In addition, benzatropine inhibits the reuptake of dopamine at nerve terminals via the dopamine transporter (SLC6A3). Dopamine-acetylcholine imbalance caused by a decrease in dopaminergic activity, is believed to be responsible for the symptoms of Parkinson's disease and extrapyramidal reactions. The dual effect of benzatropine is believed to restore the balance between these neurotransmitters.
External links