nedocromil

Ligand id: 7607

Name: nedocromil

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 121.21
Molecular weight 371.1
XLogP 1.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as an inhlation drug to alleviate bronchconstriction in asthma [1], and may be used in eye-drops to treat allergic eye reactions. The use of some formulations of this drug has been discontinued in the US.
Mechanism Of Action and Pharmacodynamic Effects
Nedocromil predominantly stabilises mast cells and inhibits their degranulation. This action supresses the release of histamine and tryptase, thus reducing the synthesis of pro-inflammatory prostaglandins and leukotrienes. The drug also inhibits the activity of other types of inflammatory cells (eg eosinophils, neutrophils, macrophages, monocytes, and platelets) which are associated with asthma. However, as mast cell stabilisation is not sufficient on its own to explain the anti-asthmatic activity of this chromone type drug, other as yet incompletely resolved mechanisms must be involved.
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