benzonatate

Ligand id: 7611

Name: benzonatate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 1
Rotatable bonds 33
Topological polar surface area 121.4
Molecular weight 603.36
XLogP 1.35
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Benzonatate is a non-narcotic oral antitussive used to reduce coughing in respiratory conditions including bronchitis, emphysema, influenza, and pneumonia.
Mechanism Of Action and Pharmacodynamic Effects
Benzonatate is believed to anesthetise stretch sensors in the lungs, activation of which is responsible for the cough reflex. However, the precise protein structure of these receptors remains elusive, but they appear to be protein complexes likely to contain voltage-gated sodium channels.
External links