secobarbital

Ligand id: 7615

Name: secobarbital

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 75.27
Molecular weight 238.13
XLogP 2.28
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Secobarbital is used short-term to treat insomnia, as a pre-operative sedative, or as an anaesthetic for short surgical, diagnostic, or therapeutic procedures.
Mechanism Of Action and Pharmacodynamic Effects
Secobarbital is a positive allosteric modulator of GABAA channels, enhancing the inhibitory effects of GABA in the CNS. The drug binds to a barbituate allosteric site [1], which is distinct from the benzodiazepine allosteric site, and from the GABA binding site. Barbiturate modulation prolongs the duration of bursts of chloride channel opening [1] and this is responsible for the anxiolytic, anticonvulsant, amnesic, sedative, hypnotic, euphoriant, and muscle relaxant properties of the drug.
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