Ligand id: 7617

Name: guaifenesin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 58.92
Molecular weight 198.09
XLogP 0.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Guaifenesin is an expectorant used to reduce chest congestion caused by the common cold, infections, or allergies. This drug is available with or without prescription in the US. Guaifenesin is often sold in fixed-mixture formulations containing codeine (antitussive) and pseudoephedrine( decongestant) to treat painful and persistent coughs with mucus buildup and nasal congestion.
Mechanism Of Action and Pharmacodynamic Effects
Guaifenesin works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier, although the precise mechanistic target of drug action is unknown.
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