Ligand id: 7618

Name: betanidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 36.42
Molecular weight 177.13
XLogP 3.16
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Betanidine is an antihypertensive drug. However, there is no information regarding approval of this drug on either the US FDA or EMA websites. Individual national approval agencies may have granted marketing authorisation for this drug. Drug formulations usually contain bethanidine sulphate.
Mechanism Of Action and Pharmacodynamic Effects
Betanidine primarily acts as an α2a adrenoceptor agonist (see the adrenoceptor family) and decreases blood pressure by suppressing renin secretion or modulating the function of the sympathetic nervous system, potentially by acting as a substrate for the norepinephrine transporter (SLC6A2).