Ligand id: 7620

Name: melphalan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 66.56
Molecular weight 304.07
XLogP 0.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Melphalan is a bifunctional alkylating agent used as a chemotherapy drug. Alkylating agents are active against both resting and rapidly dividing tumour cells. Melphalan is used in the palliative treatment of multiple myeloma and non-resectable ovarian cancer of epithelial origin. Melphalan may also have therapeutic benefit in some patients with advanced breast carcinoma (either alone or in combination with other drugs) or those suffering from polycythaemia vera.
Mechanism Of Action and Pharmacodynamic Effects
Alkylating agents inhibit tumour growth by cross-linking guanine bases in DNA double-helix strands. Drug treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death.
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