fosaprepitant

Ligand id: 7623

Name: fosaprepitant

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 9
Topological polar surface area 133.41
Molecular weight 615.12
XLogP 7.12
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Fosaprepitant is an intravenously administered prodrug of aprepitant, used to prevent nausea and vomiting induced by chemotherapy.
Mechanism Of Action and Pharmacodynamic Effects
The active metabolite of fosaprepitant, aprepitant, is a substance P analogue and acts as an antagonist of the neurokinin 1 receptor (NKR1). This prevents activation of NKR1 in the area of the medulla known as the vomiting center [2], and thereby reduces nausea and vomiting.
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