Ligand id: 7641

Name: icotinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 74.73
Molecular weight 391.15
XLogP 2.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Icotinib (as the hydrochloride salt, PubChem CID 44609731) is approved in China to treat patients with non-small cell lung cancer (NSCLC). Click here to view icotinib trials registered with ClinicalTrials.gov.
Mechanism Of Action and Pharmacodynamic Effects
Tumours carrying activating mutations of EGFR are significantly susceptible to treatment with EGFR tyrosine kinase inhibitors. The drug inhibits EGFR-driven pathways involved in cell differentiation, proliferation, angiogenesis, and apoptosis.