AZD4017

Ligand id: 7695

Name: AZD4017

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 107.83
Molecular weight 419.22
XLogP 4.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AZD4017 was originally investigated as a potential treatment for cardiovascular and metabolic disorders, in particular diabetes. Click here to view AZD4017 trials registered with ClinicalTrials.gov.
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of 11β-HSD1 reduces circulating levels of the glucocorticoid, cortisol. Elevated levels of intracellular glucocorticoids are thought to underlie the metabolic syndrome [1] which can progress to type II diabetes [4-5].