Ligand id: 7844

Name: AZD1236

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 126.08
Molecular weight 402.08
XLogP 1.45
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A Phase IIa study evaluated the effects of AZD1236 on the biomarkers of inflammation and emphysematous lung tissue degradation in patients with moderate-to-severe COPD [2]. No clinical efficacy was demonstrated but evidence of an impact on desmosine suggests potential value in longer-term treatment of COPD.