CP-547632

Ligand id: 7881

Name: CP-547632

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 12
Topological polar surface area 137.82
Molecular weight 531.08
XLogP 2.77
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
CP-547632 is a well-tolerated, orally-bioavailable VEGFR2 inhibitor investigated for the treatment of human malignancies. Two Phase II clinical trials NCT00096239 and NCT00074867 for recurrent or persistent ovarian cancer, primary peritoneal cancer, or fallopian tube cancer have been completed. There are no active trials for CP-547632 (Nov 2014).