entospletinib

Ligand id: 7889

Name: entospletinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 83.37
Molecular weight 411.18
XLogP 3.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Entospletinib is being evaluated in clinical trials for autoimmune and oncology indications. Two Phase II clinical trials are ongoing. The first is in combination with idelalisib (NCT01796470), the second is as a mono-therapy (NCT01799889), both are in subjects with relapsed or refractory hematologic malignancies.