Ligand id: 7937

Name: danusertib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 93.8
Molecular weight 474.24
XLogP 3.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
PHA-739358/danusertib has been assessed in Phase II clinical trials for hormone refractory prostate cancer (trial completed; NCT00766324), multiple myeloma (trial terminated; NCT00872300) and chronic myelogenous leukemia relapsed after imatinib mesylate or c-ABL therapy (trial status not verified since 2009; NCT00335868).