compound 89S [PMID: 19115845]

Ligand id: 8114

Name: compound 89S [PMID: 19115845]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 96.69
Molecular weight 275.12
XLogP 0.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
CDC7 is a protein kinase involved in control of the S-phase of the cell cycle, at the level of chromosmal DNA replication [1]. Inhibitors were developed as potential antineoplastics based on their ability to cause cell-cycle arrest and p53-independent tumour cell death.