compound 22 [PMID: 21823616]

Ligand id: 8116

Name: compound 22 [PMID: 21823616]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 62.19
Molecular weight 533.24
XLogP 7.99
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
ILK is reported to promote oncogenesis and tumour progression by mediating the phosphorylation of other proteins including Akt (protein kinase B), GSK3β and myosin light chain (MLC) [4-6,10-11,14]. Abberant ILK activity has been associated with the pathology of many types of cancers [1-3,7-8,12-13]. These findings make ILK a cogent target for therapeutic inhibition.