compound 31 [PMID: 23374866]

Ligand id: 8174

Name: compound 31 [PMID: 23374866]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 106.28
Molecular weight 366.17
XLogP 1.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
NIK inhibitors are considered to provide potential clinical benefit by decreasing NF-κB2 signalling in the immune system, as a treatment for chronic inflammation and autoimmune conditions.