compound 21 [PMID: 24900635]

Ligand id: 8187

Name: compound 21 [PMID: 24900635]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 7
Topological polar surface area 95.83
Molecular weight 505.15
XLogP 6.95
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Programmed necrosis (or necroptosis), is induced by TNFα and is dependent upon RIPK1 action [1]. RIPK1-dependent necroptosis is a key driver of the pathogenesis of inflammation and disease, for example in ischemia/reperfusion injury in the brain [8], retina [5] and kidney [3], and in models of myocardial infarction [6] and retinal detachment [7]. RIPK1 inhibitors would help redude such TNFα-induced pathologies.