Ligand id: 8374

Name: EMA401

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 76.07
Molecular weight 507.2
XLogP 9.83
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
EMA401 is being assessed in separate Phase II clinical trials as a potential treatment for postherpetic neuralgia (PHN) or diabetic neuropathies (May 2015).
Mechanism Of Action and Pharmacodynamic Effects
Expression of AT2R mRNA and protein, and co-localisation with pain related neurotramsmitters in human dorsal root ganglion suggests the existence of an intrinsic angiotensin driven pathway in the nervous system, which may be involved in nociception [4]. Reports of AT2R antagonist efficacy in rodent neuropathic pain [6-7] and in human post-herpetic neuralgia [3] support this hypothesis. Further evidence suggests a role for AT2R in modulating both pain signalling and neurite outgrowth [1].