Summary of Clinical Use

Ularitide is being evaluated in Phase 3 clinical trial as a potential treatment for acute heart failure [1-2].

Mechanism Of Action and Pharmacodynamic Effects

Urodilatin is a kidney specific fragment of ANP. Urodilatin induces strong diuresis and natriuresis, being invloved in the regulation of body fluid volume and water-electrolyte excretion. Ularitide effectively mimics ANP's inhibitory action on the renin-angiotensin-aldosterone system which is activated early in the development of congestive heart failure (CHF) to stimulate water excretion via the kidneys [2].