Ligand id: 85

Name: fluspirilene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 35.58
Molecular weight 475.24
XLogP 7.9
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Long acting first generation anti-psychotic drug used to treat schizophrenia. Administered by intramuscular injection. However, there is no information regarding approval for clinical use of fluspirilene on the US FDA website. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Like the other diphenylbutylpiperidine antipsychotics, this drug's beneficial clinical oucomes likely arise from agonist activity at dopamine receptors.