Ligand id: 86

Name: haloperidol

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View more information in the IUPHAR Pharmacology Education Project: haloperidol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 40.54
Molecular weight 375.14
XLogP 4.5
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the management of psychotic disorders including schizophrenia, and in the control of Tourettes syndrome. Also used for the control of ADHD in children and for the prevention of severe nausea and vomiting.
Mechanism Of Action and Pharmacodynamic Effects
The precise mechanism underlying the therapeutic effects of haloperidol remains incompletely understood, but antagonism of dopamine receptors plays a significant role. Haloperidol appears to have strong central antidopaminergic action accompanied by a much weaker central anticholinergic action. Antiemetic activity may be caused by direct inhibition of dopamine receptors in the chemoreceptor trigger zone (CTZ).