Ligand id: 87

Name: iloperidone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 64.8
Molecular weight 426.2
XLogP 4.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat schizophrenia.
Mechanism Of Action and Pharmacodynamic Effects
Iloperidone is a bifunctional drug, antagonising dopamine receptors and serotonin 5-HT receptors, with higher efficacy at the dopanine receptor compared to the serotonin receptors. Such action classifies this drug as an atypical antipsychotic. Inhibition of these receptors leads to an improvement in the psychotic symptoms experienced by schizophrenia patients.