mebeverine

Ligand id: 9011

Name: mebeverine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: mebeverine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 14
Topological polar surface area 57.23
Molecular weight 429.25
XLogP 5.11
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Mebeverine is approved to treat the abdominal cramping associated with irritable bowel syndrome (IBS) and associated conditions. It is a generic drug available internationally under many brand names (see Drugs.com's international drug page for mebeverine). In many countries this is sold as an over the counter (OTC) drug.
Mechanism Of Action and Pharmacodynamic Effects
Mebeverine is an antimuscarinic agent acting on gut receptors to relax the intestinal smooth muscle, without affecting motility.
External links