Ligand id: 9072

Name: cinnarizine

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View more information in the IUPHAR Pharmacology Education Project: cinnarizine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 6.48
Molecular weight 368.23
XLogP 9.87
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat motion sickness and for the control of vestibular disorders such as vertigo, tinnitus, nausea and vomiting such as is seen in Meniere's Disease.
This drug does not appear to have US FDA or EMA marketing authorisation, but it has been approved for use by many national authorisation agencies.
Mechanism Of Action and Pharmacodynamic Effects
Cinnarizine interferes with the signal transmission between the vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus, to abolish the disparity of signal processing between inner ear motion receptors and the visual senses which is believed to drive feelings of nausea and promote vomiting in indicated conditions.
Cinnarizine's calcium channel blocking activity causes cerebral vasorelaxation, with potential cognitive function enhancing (nootropic) ability.
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