dacarbazine

Ligand id: 9075

Name: dacarbazine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: dacarbazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 95.44
Molecular weight 182.09
XLogP -1.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Dacarbazine is useful for the treatment of malignant melanoma and Hodgkin's disease.
Mechanism Of Action and Pharmacodynamic Effects
Dacarbazine alkylates and cross-links DNA, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
External links