Synonyms: Emcyt® | Estracyt®
estramustine is an approved drug (FDA (1981))
Compound class:
Synthetic organic
Comment: Estramustine is a synthetic analogue combining estradiol and nornitrogen mustard. It is a DNA alkylating agent with antineoplastic activity.
Marketed formulations contain estramustine phosphate sodium (PubChem CID 444000). View more information in the IUPHAR Pharmacology Education Project: estramustine |
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No information available. |
Summary of Clinical Use |
Estramustine is approved to treat metastatic or progressive prostate cancer. |
Mechanism Of Action and Pharmacodynamic Effects |
Estramustine alkylates and cross-links DNA, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. |
External links |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com |