Ligand id: 9076

Name: estramustine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 49.77
Molecular weight 439.17
XLogP 6.7
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Estramustine is approved to treat metastatic or progressive prostate cancer.
Mechanism Of Action and Pharmacodynamic Effects
Estramustine alkylates and cross-links DNA, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
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