compound 6j [PMID: 27219676]

Ligand id: 9230

Name: compound 6j [PMID: 27219676]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 75.94
Molecular weight 492.19
XLogP 5.32
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Accumulating evidence suggests a critical link between dysregulated DDR1 and pulmonary fibrosis [1], human cancers and other inflammatory conditions [2,4]. DDR1 inhibitors are therefore being investigated for clinical application in fibrotic disease [3].