Ligand id: 9326

Name: abediterol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 13
Topological polar surface area 90.82
Molecular weight 460.22
XLogP 5.09
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Phase 2a first-in-patient clinical trial results are published in [2]. The agent was generally well tolerated, producing a safe, potent, rapid and long-acting bronchodilatory effect in patients with persistent mild-to-moderate asthma.
Mechanism Of Action and Pharmacodynamic Effects
LABAs produce long-acting bronchodilatory effect, with clinical utility in managing airway obstruction, for example in asthma and COPD. LABAs are recommended to be used in conjunction with inhaled corticosteroids for asthma management.