Ligand id: 9540

Name: AF-219

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 164.82
Molecular weight 353.12
XLogP 0.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AF-219 has completed many Phase 2 clinical trials (click here to link to the list of Phase 2 AF-219 trials registered with Phase 2 results evaluating AF-219 in refactory chronic cough (NCT01432730) are reported in [1]. The following references highlight the clinical potential of ATP antagonism in human diseases: [2,4].