Ligand id: 965

Name: domperidone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 67.92
Molecular weight 425.16
XLogP 3.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Domperidone is used to manage dyspepsia, heartburn, epigastric pain, nausea, and vomiting. In some countries, domperidone is self-prescribed or prescribed for off-label use to enhance lactation. Domperidone-containing medicines are widely available over-the-counter or prescription-only medicines. Neither the US FDA or European Medicines Agency (EMA) websites carry information regarding marketing approval for domperidone, although both note that approval is granted by individual national agencies. The EMA is reviewing the benefit-risk balance of domperidone-containing medicines (March 2013)
Mechanism Of Action and Pharmacodynamic Effects
Domperidone blocks dopamine receptors in the gut and in the part of the brain linked to vomiting (the chemoreceptor trigger zone, located just outside the blood brain barrier). This results in increased esophageal and gastric peristalsis, such that food moves more quickly through the stomach and into the intestine. This helps prevent vomiting and reduces feelings of sickness, bloating and fullness. Domperidone also stimulates prolactin release.